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Advances in Cell Mechanics
Kategorie Beschreibung
036aXA-DE
037beng
077a35228403X Druckausg.: ‡Advances in Cell Mechanics
087q978-3-642-17589-3
100 Li, Shaofan
104bSun, Bohua ¬[Hrsg.]¬
331 Advances in Cell Mechanics
410 Berlin, Heidelberg
412 Higher Education Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg
425 2011
425a2011
433 Online-Ressource (XIV, 316 p, online resource)
451bSpringerLink. Bücher
501 Description based upon print version of record
517 Title Page; Copyright Page; Preface; Table of Contents; Contributors; Chapter 1 Modeling and Simulations of the Dynamics of Growing Cell Clusters; 1.1 Introduction; 1.2 Single cell geometry and kinematics; 1.2.1 The continuum model; 1.2.2 The numerical model for the cell geometry; 1.3 Single cell equilibrium and material model; 1.3.1 Cell equilibnum; 1.3.2 The material model; 1.3.3 Determination of material constants; 1.4 Modeling cell interactions; 1.4.1 Cell-to-cell contact; 1.4.2 Cell-to-cell adhesion; 1.4.3 Cell-to-cell interaction test; 1.5 Modeling the cell life cycle. 1.6 Details of the numerical implementation1.6.1 The finite element model; 1.6.2 Contact/adhesion interface detection; 1.6.3 Time integration; 1.6.4 Parallelization; 1.7 Numerical results; 1.8 Summary and conclusions; Acknowledgements; References; Chapter 2 Multiscale Biomechanical Modeling of Stem Cell-Extracellular Matrix Iriteractlons; 2.1 Introduction; 2.2 Cell and ECM modeling; 2.2.1 Basic hypothesis and assumptions; 2.2.2 Hyperelastic model; 2.2.3 Liquid crystal model; 2.3 Contact and adhesion models for cell-substrate interactions. 2.3.1 The adhesive body force with continuum mechanics contact2.3.2 The cohesive contact model; 2.4 Meshfree Galerkin formulation and the computational algorithm; 2.5 Numerical simulations; 2.5.1 Validation of the material models; 2.5.2 Cell response in four different stiffness substrates; 2.5.3 Cell response to a stiffness-varying substrate; 2.5.4 Comparison of two different contact algorithms; 2.5.5 Three-dimensional simulation of cell spreading; 2.6 Discussion and conclusions; Acknowledgements; References; Chapter 3 Modeling of Proteins and Their Interactions with Solvent; 3.1 Introduction. 3.2 Classical molecular dynamics3.2.1 Coarse-grained model; 3.2.1.1 Normal mode analysis; 3.2.1.2 Go model; 3.2.1.3 Elastic network model; 3.2.2 High performance computing; 3.3 Principal component analysis; 3.3.1 Three oscillators system analysis with PCA; 3.3.2 Quasi- harmonic analyeis; 3.3.3 Equilibrium conformational analysis; 3.4 Methods and procedures; 3.4.1 Framework; 3.4.2 Overlap coefficients; 3.4.3 Correlation analysis; 3.4.4 peA with MD simulation; 3.4.5 Kabsch algorithm; 3.4.6 Positional correlation matrix; 3.4.7 Cluster analvsis; 3.5 MD simulation with T4 lysozyme. 3.5.1 Equilibration measures3.5.2 Fluctuation analysis; 3.5.3 Mode selection and evaluation; 3.5.4 Eigenvalue analysis; 3.5.5 Overlap evaluation; 3.5.6 Identification of slow conformational flexibilitv; 3.5.7 Correlation analysis of T 4 lysozyme; 3.6 Hemoglobin and sickle cell anemia; 3.6.1 Molecular dynamic simulation with NAMD; 3.6.2 Conformational change analysis; 3.6.3 PCA analysis; 3.6.4 Correlation analysis with HbS interaction; 3.7 Conclusion; Acknowledgements; References. Chapter 4 Structural, Mechanical and Functional Properties of Intermediate Filaments from the Atomistic to the Cellular Scales
527 Druckausg.: ‡Advances in Cell Mechanics
540aISBN 978-3-642-17590-9
700 |TGMD
700 |TEC009070
700 |SCI041000
700 |*92-06
700 |92C05
700 |92C10
700 |92C15
700 |92C17
700 |92C37
700b|620.1
700b|571.63430113
700b|571.6
700c|TA349-359
700g1271586320 WD 2300
750 "Advances in Cell Mechanics" presents the latest developments in cell mechanics and biophysics, mainly focusing on interdisciplinary research in cell biology and the biophysics of cells. Moreover, a unique feature of the book is its emphasis on the molecular and complex continuum modeling and simulations of the cells. It may be the first work that brings rigorous and quantitative scientific analysis and state-of-the-art simulation technology into cell biology research. The book is intended for researchers and graduate students working in the fields of molecular cell biology, bio-engi
902s 209170123 Zelle
902s 208867600 Biomechanik
902s 209763132 Computersimulation
902f |Aufsatzsammlung
012 355113368
081 Li, Shaofan: Advances in Cell Mechanics
100 Springer E-Book
125aElektronischer Volltext - Campuslizenz
655e$uhttp://dx.doi.org/10.1007/978-3-642-17590-9
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